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MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes
Nishio M, Yamaguchi K, Otani J, Yuguchi K, Kohno D, Sasaki T, Kitamura T, Shinohara M, Soga T, Kawamura K, Sasaki AT, Oshima M, Hikasa H, Woo M, Sasaki T, Nishina H, Nakao K, Maehama T, Suzuki A.
Journal:
Proc Natl Acad Sci U S A.
2025
Year:
Vol.&Pages:
122(17)
e2424741122
DOI :
10.1073/pnas.2424741122.
40258148
PMID:
Pubmed URL:
PI5P4K inhibitors: Promising opportunities and challenges.(Review)
Takeuchi K*, Nagase L, Kageyama S, Kanoh H, Oshima M, Ogawa-Iio A, Ikeda Y, Fujii Y, Kondo S, Osaka N, Masuda T, Ishihara T, Nakamura Y, Hirota Y, Sasaki T, Senda T*, Sasaki AT*.
Journal:
FEBS J.
2024
Year:
Vol.&Pages:
in press
DOI :
PMID:
Pubmed URL:
A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion
Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Sasaki AT*.
Journal:
Biochem. Biophys. Res. Commun.
2024
Year:
Vol.&Pages:
23:718
149981
DOI :
10.1016/j.bbrc.2024.149981
38735134
PMID:
Pubmed URL:
Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay
Kopra K, Mahran R, Yli-Hollo T, Tabata S, Vuorinen E, Fujii Y, Vuorinen I, Ogawa-Iio A, Hirayama A, Soga T, Sasaki AT, Härmä H.
Journal:
Anal Bioanal Chem.
2023
Year:
Vol.&Pages:
415(27)
6689-6700
DOI :
10.1007/s00216-023-04944-9
37714971
PMID:
Pubmed URL:
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells
Yoshiki Ikeda, Mindy I. Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Mika Sasaki, Yoshihisa Hirota, Rajan Pragani, Min Shen, Matthew B. Boxer, Koh Takeuchi, Toshiya Senda, Anton Simeonov, Atsuo T. Sasaki
Journal:
Biochemical and Biophysical Research Communications
2023
Year:
Vol.&Pages:
679
116-121.
DOI :
10.1016/j.bbrc.2023.08.050
37683456
PMID:
Pubmed URL:
Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ
Takeuchi K, Senda M, Ikeda Y, Okuwaki K, Fukuzawa K, Nakagawa S, Sasaki M, Sasaki AT, Senda T.
Journal:
FEBS J
2023
Year:
Vol.&Pages:
290(18)
4419-4428
DOI :
10.1111/febs.16763
36856076
PMID:
Pubmed URL:
IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia.
Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Kinouchi C, Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O'Brien E, Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T, Goyama S.
Journal:
EMBO Mol Med.
2023
Year:
Vol.&Pages:
15(1)
e15631
DOI :
10.15252/emmm.202115631.
36453131
PMID:
Pubmed URL:
Beyond Warburg: LDHA activates RAC for tumour growth.
Osaka N, Sasaki AT*
Journal:
Nat Metab
2022
Year:
Vol.&Pages:
4(12)
1623-1625
DOI :
10.1038/s42255-022-00709-3.
36536138.
PMID:
Pubmed URL:
The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.
Takeuchi K*, Ikeda Y, Senda M, Harada A, Okuwaki K, Fukuzawa K, Nakagawa S, Yu HY, Nagase L, Imai M, Sasaki M, Lo YH, Ito D, Osaka N, Fujii Y, Sasaki AT*, Senda T*. *Co-correspondence
Journal:
Structure
2022
Year:
Vol.&Pages:
S0969-2126(22)
00131-9
DOI :
10.1016/j.str.2022.04.004.
35504278
PMID:
Pubmed URL:
Epigenetic upregulation of Schlafen11 renders WNT-and SHH-activated medulloblastomas sensitive to cisplatin.
Nakata S, Murai J, Okada M, Takahashi H, Findlay TH, Malebranche K, Parthasarathy A, Miyashita S, Gabdulkhaev R, Benkimoun I, Druillennec S, Chabi S, Hawkins E, Miyahara H, Tateishi K, Yamashita S, Yamada S, Saito T, On J, Watanabe J, Tsukamoto Y, Yoshimura J, Oishi M, Nakano T, Imamura M, Imai C, Yamamoto T, Takeshima H, Sasaki AT, Rodriguez FJ, Nobusawa S, Varlet P, Pouponnot C, Osuka S, Pommier Y, Kakita A, Fujii Y, Raabe EH, Eberhart CG, Natsumeda M.
Journal:
Neuro Oncol
2022
Year:
Vol.&Pages:
25(5)
899-912
DOI :
10.1093/neuonc/noac243.
36273330
PMID:
Pubmed URL:
Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers.
Takashima T, Taniyama D, Sakamoto N, Yasumoto M, Asai R, Hattori T, Honma R, Thang PQ, Ukai S, Maruyama R, Harada K, Kuraoka K, Tanabe K, Sasaki AT, Ohdan H, Morii E, Murai J, Yasui W.
Journal:
Br J Cancer
2021
Year:
Vol.&Pages:
125(1)
65-77
DOI :
10.1038/s41416-021-01364-3
33785877
PMID:
Pubmed URL:
TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers.
Nakasuka F, Tabata S, Sakamoto T, Hirayama A, Ebi H, Yamada T, Umetsu K, Ohishi M, Ueno A, Goto H, Sugimoto M, Nishioka Y, Yamada Y, Tomita M, Sasaki AT, Yano S, Soga T.
Journal:
Commun Biol
2021
Year:
Vol.&Pages:
4(1)
782
DOI :
10.1038/s42003-021-02323-7.
34168290
PMID:
Pubmed URL:
SI-MOIRAI:A new method to identify and quantify the metabolic fate of nucleotides.
Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT*.
Journal:
J Biochem
2022
Year:
Vol.&Pages:
170(6)
699-711
DOI :
10.1093/jb/mvab077.
34244779
PMID:
Pubmed URL:
Mycophenolate mofetil hepatotoxicity associated with mitochondrial abnormality in liver transplant recipients and mice.
Wallen M, Mitsinikos T, Yanni G, Sasaki AT, Thomas D. J.
Journal:
Ped. Gastro. Nutri.
2021
Year:
Vol.&Pages:
73(4)
463-470
DOI :
10.1097/MPG.0000000000003171.
34016874
PMID:
Pubmed URL:
Reuse of Molecules for Glioblastoma Therapy.
Koehler A, Karve A, Desai P, Arbiser J, Plas DR, Qi X, Read RD, Sasaki AT, Gawali VS, Toukam DK, Bhattacharya D, Kallay L, Pomeranz Krummel DA, Sengupta S.
Journal:
Pharmaceuticals (Basel)
2021
Year:
Vol.&Pages:
14(2)
99
DOI :
10.3390/ph14020099.
33525329
PMID:
Pubmed URL:
Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema.(Review)
Biplab Dasgupta, Yoshihisa Hirota, Yuki Fujii, Natsuki Osaka, Doshun Ito, David R. Plas, Atsuo T. Sasaki*.
Journal:
In: Gliomas. Brisbane (AU): Exon Publications
2021
Year:
Vol.&Pages:
Chapter 7
DOI :
10.36255/exonpublications.gliomas.2021.chapter7
34038050
PMID:
Pubmed URL:
Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma. (Review)
Garrett M, Fujii Y, Osaka N, Ito D, Hirota Y, Sasaki AT*
Journal:
In: Gliomas [Internet]. Brisbane (AU)
2021
Year:
Vol.&Pages:
Chapter 4
DOI :
10.36255/exonpublications.gliomas.2021.chapter4
34038049
PMID:
Pubmed URL:
Integration of Molecular Analysis, Cutting-edge Mouse Genetic Models and Proton Therapy to Improve Outcomes for Glioma Patients.(Review)
Soma Sengupta, Luke E. Pater, Daniel Pomeranz Krummel, Bruce J. Aronow, Yoshihisa Hirota, Timothy N. Phoenix, Atsuo T. Sasaki*
Journal:
In: Gliomas. Brisbane (AU): Exon Publications
2021
Year:
Vol.&Pages:
Chapter 5
DOI :
10.36255/exonpublications.gliomas.2021.chapter5
34038048
PMID:
Pubmed URL:
Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. (Review)
Osaka N, Hirota Y, Ito D, Ikeda Y, Kamata R, Fujii Y, Chirasani VR, Campbell SL, Takeuchi K, Senda T, Sasaki AT*.
Journal:
Front Mol Biosci
2021
Year:
Vol.&Pages:
8
707439
DOI :
10.3389/fmolb.2021.707439.
34307463
PMID:
Pubmed URL:
Metabolic compartmentalization at the leading edge of metastatic cancer cells. (Review)
Kamata R, Coutinho K, Inoue T, Sasaki AT*.
Journal:
Front Oncol
2020
Year:
Vol.&Pages:
10
554272
DOI :
10.3389/fonc.2020.554272.
33224873
PMID:
Pubmed URL:
GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism.
Kofuji S, Sasaki AT*.
Journal:
J Biochem
2020
Year:
Vol.&Pages:
168(4)
319-328
DOI :
10.1093/jb/mvaa085.
32702086
PMID:
Pubmed URL:
Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase.
Takeuchi K, Ikeda Y, Senda M, Harada A, Okuwaki K, Fukuzawa K, Nakagawa S, Yu H, Nagase L, Imai M, Sasaki M, Lo YH, Sasaki AT*, Senda T*.
Journal:
bioRxiv
2020
Year:
Vol.&Pages:
DOI :
PMID:
Pubmed URL:
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Manz TD, Sivakumaren SC, Yasgar A, Hall MD, Davis MI, Seo HS, Card JD, Ficarro SB, Shim H, Marto JA, Dhe-Paganon S, Sasaki AT, Boxer MB, Simeonov A, Cantley LC, Shen M, Zhang T, Ferguson FM, Gray NS.
Journal:
ACS Med Chem Lett.
2019
Year:
Vol.&Pages:
11(3)
346-352
DOI :
10.1021/acsmedchemlett.9b00402.
32184968
PMID:
Pubmed URL:
Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.(Review)
Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT*.
Journal:
Cancers (Basel)
2019
Year:
Vol.&Pages:
11(9)
pii: E1346
DOI :
10.3390/cancers11091346.
31514446
PMID:
Pubmed URL:
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.
Kofuji S, Yoshino H, Sumita K, Malhotra A, Sasaki M, Kaori K, Takiko D, Majd N, Hirayama A, Soga T, Pater L, Gozal Y, Wse-Draper T, Gogela S, Kendler A, Warnick RE, Chow L, Horbinski C, Warren Kofuji, S., Hirayama, A., Eberhardt, A., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S., Ban, Y., Asano, M., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., Deberardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H., and Sasaki, AT*.
Journal:
Nat Cell Biol.
2019
Year:
Vol.&Pages:
21(8)
1003-1014.
DOI :
10.1038/s41556-019-0363-9.
31371825
PMID:
Pubmed URL:
Identification of lysine methylation in the core GTPase domain by GoMADScan.
Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT*.
Journal:
PLoS One
2019
Year:
Vol.&Pages:
14(8)
e0219436
DOI :
10.1371/journal.pone.0219436.
31390367
PMID:
Pubmed URL:
Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria.
Miller TE, Henkels KM, Huddleston M, Salisbury R, Hussain SM, Sasaki AT, Cho KJ.
Journal:
J Cell Sci
2019
Year:
Vol.&Pages:
132(16)
jcs231886
DOI :
10.1242/jcs.231886
31331963
PMID:
Pubmed URL:
Dynamic Compartmentalization of Purine Nucleotide Metabolic Enzymes at Leading Edge in Highly Motile Renal Cell Carcinoma.
Wolfe, K., Kofuji, S., Yoshino, H., Sasaki, M., Okumura, K., and Sasaki, AT*.
Journal:
Biochem Biophys Res Commun
2019
Year:
Vol.&Pages:
516(1)
50-56
DOI :
10.1016/j.bbrc.2019.05.190.
31196624
PMID:
Pubmed URL:
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J.
Journal:
Cell
2018
Year:
Vol.&Pages:
172(1-2)
90-105
DOI :
10.1016/j.cell.2017.11.031.
29249359
PMID:
Pubmed URL:
In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells.
Han D, Sasaki M, Yoshino H, Kofuji S, AT Sasak AT, Steckl AJ.
Journal:
J. Drug Deli. Sci. Tech.
2017
Year:
Vol.&Pages:
7
45-50
DOI :
PMID:
Pubmed URL:
Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.
Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR.
Journal:
Cell Rep
2017
Year:
Vol.&Pages:
18(9)
2088-2095
DOI :
10.1016/j.celrep.2017.02.022
28249155
PMID:
Pubmed URL:
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL. Edinger.
Journal:
J. Clin. Invest.
2016
Year:
Vol.&Pages:
126
4088-4102
DOI :
10.1172/JCI87148.
27669461
PMID:
Pubmed URL:
Use of multiple cryoprotectants to improve diffraction quality from protein crystals.
Senda M, Hayashi T, Hatakeyama M, Takeuchi K, Sasaki AT, and Senda T.
Journal:
Cryst. Growth Des.
2016
Year:
Vol.&Pages:
63(Pt 11)
1139-53
DOI :
10.1107/S0907444907045040.
18007029
PMID:
Pubmed URL:
Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format.
Davis MI, Sasaki AT, Simeonov A.
Journal:
Methods Mol Biol
2016
Year:
Vol.&Pages:
1376
1-9
DOI :
10.1007/978-1-4939-3170-5_1.
26552670
PMID:
Pubmed URL:
Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells.
Takeuchi K, Senda M, Lo YH, Kofuji S, Ikeda Y, Sasaki AT*, Senda T.
Journal:
FEBS J
2016
Year:
Vol.&Pages:
283(19)
3556-3562
DOI :
10.1111/febs.13739.
27090388
PMID:
Pubmed URL:
The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis.
Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT*.
Journal:
Mol Cell
2016
Year:
Vol.&Pages:
61(2)
187-98
DOI :
10.1016/j.molcel.2015.12.011.
26774281
PMID:
Pubmed URL:
Degaradation of Activated K-Ras Orthologue via K-Ras Specific Lysine Residues is Required for Cytokinesis.
Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT*.
Journal:
J Biol Chem
2014
Year:
Vol.&Pages:
289(7)
3950-9
DOI :
10.1074/jbc.M113.531178.
24338482
PMID:
Pubmed URL:
A Review of the Potential Utility of Mycophenolate Mofetil as a Cancer Therapeutic.
Majd N, Sumita K, Yoshino H, Chen D, Terakawa J, Daikoku T, Kofuji S, Curry R, Wise-Draper T, Warnick RE, Guarnaschelli J and Sasaki AT*.
Journal:
J. Cancer Res.
2014
Year:
Vol.&Pages:
2014
Article ID 423401
DOI :
PMID:
Pubmed URL:
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors.
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC.
Journal:
Cell
2013
Year:
Vol.&Pages:
155
844-857
DOI :
10.1016/j.cell.2013.09.057.
24209622
PMID:
Pubmed URL:
Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination.
Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL.
Journal:
J Biol Chem
2013
Year:
Vol.&Pages:
288(52)
36856-62
DOI :
10.1074/jbc.C113.525691.
24247240
PMID:
Pubmed URL:
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.
Davis MI*, Sasaki AT*, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. (*These authors contributed equally to this work)
Journal:
PLoS One
2013
Year:
Vol.&Pages:
8(1)
e54127
DOI :
10.1371/journal.pone.0054127.
23326584
PMID:
Pubmed URL:
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki AT, Aronow B, Warnick RE, Lawler S, Driscoll JJ.
Journal:
Sci Rep
2013
Year:
Vol.&Pages:
3
2392
DOI :
10.1038/srep02392.
23928793
PMID:
Pubmed URL:
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. (Featured in the Nat Rev Mol Cell Biol 2012 Dec 19. doi: 10.1038/nrm3500: Cell signalling: How monoubiquitylation keeps RAS active.)
Baker R, Lewis SM, Sasaki AT, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL.
Journal:
Nat. Stru. Mol. Biol
2013
Year:
Vol.&Pages:
20
46-52
DOI :
10.1038/nsmb.2430
23178454
PMID:
Pubmed URL:
Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules.
Fujimura K, Sasaki AT, Anderson P.
Journal:
Nucleic Acids Res.
2012
Year:
Vol.&Pages:
40
8099-8110
DOI :
10.1093/nar/gks566
22718973
PMID:
Pubmed URL:
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State.
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.
Journal:
Cell
2012
Year:
Vol.&Pages:
149
49-62
DOI :
10.1016/j.cell.2012.02.030
22401813
PMID:
Pubmed URL:
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP.
Journal:
J. Cell Physiol.
2012
Year:
Vol.&Pages:
227(4)
1709-20
DOI :
10.1002/jcp.22895
21688263
PMID:
Pubmed URL:
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. (*Featured article in this issue: Science 2011;334:1219-20.)
Anastasiou D, Poulogiannis G, Asara JM, Bellinger G, Vander Heiden MG, Sasaki AT, Locasale JW and Cantley LC.
Journal:
Science
2011
Year:
Vol.&Pages:
334
1278-83
DOI :
10.1126/science.1211485
22052977
PMID:
Pubmed URL:
Ubiquitination of Ras enhances activation and facilitates binding to PI 3-Kinase and Raf. (* Highlighted as the cover page and come with perspective Science Signaling. 2011;4:12.) (*This paper was evaluated and selected by the Faculty of 1000 Biology member)
Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC.
Journal:
Science Signaling.
2011
Year:
Vol.&Pages:
4
1-9
DOI :
10.1126/scisignal.2001518
21386094
PMID:
Pubmed URL:
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Locasale JW, Grassian AR, Bass AJ, Heffron G, Metallo CM, Sharfi H, Sasaki AT, Anastasiou D, Vokes NI, Sasaki M, Ligon AH, Beroukhim R, Stephanopoulos G, Asara JM, Meyerson M, Wagner G, Brugge JS, Cantley LC and Vander Heiden MG.
Journal:
Nature Genetics
2011
Year:
Vol.&Pages:
43
869-74
DOI :
10.1038/ng.890.
21804546
PMID:
Pubmed URL:
A fluorescent reporter of AMPK activity and cellular energy stress. (* Featured article in this issue of Cell Metabolism) (*This paper was evaluated and selected by the Faculty of 1000 Biology member)
Thou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC.
Journal:
Cell Metabolism.
2011
Year:
Vol.&Pages:
13(4)
476-486
DOI :
10.1016/j.cmet.2011.03.006.
21459332
PMID:
Pubmed URL:
Characterization of KRAS rearrangements in metastatic prostate cancer. (*Come with spotlight Cancer Discovery. 2011;1:12-13.)
Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Robinson D, Cao Q, Prensner JR, Yocum AK, Pflueger D, Wang R, Jing X, Fries DF, Asangani IA, Li Y, Cao X, Kumar-Sinha C, Kahoud ER, Omenn GS, Rubin MA, Gopalan A, Reuter V, Palanisamy N, Varambally S, Cantley LC, and Chinnaiyan AM.
Journal:
Cancer Discovery.
2011
Year:
Vol.&Pages:
1
35-43
DOI :
10.1158/2159-8274.CD-10-0022
22140652
PMID:
Pubmed URL:
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.
Charest PG, Shen Z, Lakoduc A, Sasaki AT, Briggs S, Firtel RA.
Journal:
Dev. Cell
2010
Year:
Vol.&Pages:
18
737-479
DOI :
10.1016/j.devcel.2010.03.017
20493808
PMID:
Pubmed URL:
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP.
Journal:
J Clin Invest.
2008
Year:
Vol.&Pages:
118
3065-74
DOI :
10.1172/JCI34739
18725988
PMID:
Pubmed URL:
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. (* Highlighted in J. Cell Biol. 2007;178:180.)
Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K Sundheimer LW, Meili R, Devreotes PN, Firtel RA.
Journal:
J. Cell Biol.
2007
Year:
Vol.&Pages:
178
185-191
DOI :
10.1083/jcb.200611138
17635933
PMID:
Pubmed URL:
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.
Sasaki AT, Firtel RA.
Journal:
Eur. J. Cell Biol.
2006
Year:
Vol.&Pages:
85(9-10)
873-95
DOI :
10.1016/j.ejcb.2006.04.007.
16740339
PMID:
Pubmed URL:
Role of PI3 kinases in chemotaxis in dictyostelium.
Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA.
Journal:
J Biol Chem.
2007
Year:
Vol.&Pages:
283
11874-84
DOI :
10.1074/jbc.M610984200
17331950
PMID:
Pubmed URL:
Suppressor of cytokine signaling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A.
Journal:
Gut.
2006
Year:
Vol.&Pages:
55(2)
212-9
DOI :
10.1136/gut.2004.062653
16120757
PMID:
Pubmed URL:
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR, Parent CA, Firtel RA.
Journal:
Mol Biol Cell.
2005
Year:
Vol.&Pages:
16(10)
4572-83
DOI :
10.1091/mbc.e05-04-0342
16079174
PMID:
Pubmed URL:
Finding the way: directional sensing and cell polarization through Ras signalling.
Sasaki AT, Firtel RA.
Journal:
Novartis Found Symp.
2005
Year:
Vol.&Pages:
269
73-87
DOI :
16355536
PMID:
Pubmed URL:
Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.
Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura K, Nishimura J, Yoshimura A.
Journal:
Nat Neurosci.
2005
Year:
Vol.&Pages:
8(7)
855-7
DOI :
10.1038/nn1485
15937482
PMID:
Pubmed URL:
Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells.
Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, Saito N.
Journal:
Biochem Biophys Res Commun.
2004
Year:
Vol.&Pages:
325(3)
843-51
DOI :
10.1016/j.bbrc.2004.10.102
15541367
PMID:
Pubmed URL:
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. (*This paper was evaluated and selected by the Faculty of 1000 Biology member)
Sasaki AT, Chun C, Takeda K, Firtel RA.
Journal:
J Cell Biol
2004
Year:
Vol.&Pages:
167(3)
505-18
DOI :
10.1083/jcb.200406177
15534002
PMID:
Pubmed URL:
Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.
Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A.
Journal:
J Biol Chem
2004
Year:
Vol.&Pages:
279(50)
52543-51
DOI :
10.1074/jbc.M405189200
15465815
PMID:
Pubmed URL:
Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation.
Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A.
Journal:
J Immunol.
2004
Year:
Vol.&Pages:
173(2)
1390-8
DOI :
10.4049/jimmunol.173.2.1390
15240735
PMID:
Pubmed URL:
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A.
Journal:
Cell Cycle.
2003
Year:
Vol.&Pages:
2(4)
281-282
DOI :
10.1038/ncb978.
12717443
PMID:
Pubmed URL:
CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation.
Endo T, Sasaki A, Minoguchi M, Joo A, Yoshimura A.
Journal:
J Biochem (Tokyo)
2003
Year:
Vol.&Pages:
133(1)
109-13
DOI :
10.1093/jb/mvg004
12761205
PMID:
Pubmed URL:
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. (*Highlighted in Nat. Cell Biol. 2003 5: 377-379)
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A.
Journal:
Nat Cell Biol.
2003
Year:
Vol.&Pages:
5(5)
427-32
DOI :
10.1038/ncb978
12717443
PMID:
Pubmed URL:
The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.
Sasaki A, Inagaki-Ohara K, Yoshida T, Yamanaka A, Sasaki M, Yasukawa H, Koromilas AE, Yoshimura A.
Journal:
J Biol Chem.
2003
Year:
Vol.&Pages:
278(4)
2432-6
DOI :
10.1074/jbc.C200608200
12459551
PMID:
Pubmed URL:
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F.
Journal:
J Biol Chem.
2003
Year:
Vol.&Pages:
278(1)
661-71
DOI :
10.1074/jbc.M210552200
12403768
PMID:
Pubmed URL:
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.
Sasaki A, Taketomi T, Wakioka T, Kato R, Yoshimura A.
Journal:
J Biol Chem
2001
Year:
Vol.&Pages:
276(39)
36804-8
DOI :
10.1074/jbc.C100386200
11495895
PMID:
Pubmed URL:
Spred is a Sprouty-related suppressor of Ras signalling.
Wakioka T, *Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A. (*These authors contributed equally to this work)
Journal:
Nature.
2001
Year:
Vol.&Pages:
412(6847)
647-51
DOI :
10.1038/35088082
11493923
PMID:
Pubmed URL:
JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.
Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ.
Journal:
Blood.
2001
Year:
Vol.&Pages:
97(1)
221-6
DOI :
10.1182/blood.v97.1.221
11133764
PMID:
Pubmed URL:
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.
Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A.
Journal:
J Biol Chem.
2000
Year:
Vol.&Pages:
275(38)
29338-47.
DOI :
10.1074/jbc.M003456200
10882725
PMID:
Pubmed URL:
CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.
Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu M, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ.
Journal:
J Biol Chem.
1999
Year:
Vol.&Pages:
274(42)
30266-72.
DOI :
10.1074/jbc.274.42.30266
10514520
PMID:
Pubmed URL:
SOCS3 is essential in the regulation of fetal liver erythropoiesis.
Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN.
Journal:
Cell.
1999
Year:
Vol.&Pages:
98(5)
617-27.
DOI :
10.1016/s0092-8674(00)80049-5
10490101
PMID:
Pubmed URL:
7. Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 1999;4(6):339-51.
Journal:
Year:
Vol.&Pages:
DOI :
PMID:
Pubmed URL:
6. Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A. APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. Leukemia. 1999;13(5):760-7.
Journal:
Year:
Vol.&Pages:
DOI :
PMID:
Pubmed URL:
5. Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999;18(5):1309-20.
Journal:
Year:
Vol.&Pages:
DOI :
PMID:
Pubmed URL:
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.
Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A.
Journal:
Oncogene.
1999
Year:
Vol.&Pages:
18(3)
759-67.
DOI :
10.1038/sj.onc.1202326
9989826
PMID:
Pubmed URL:
CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells.
Suzuki R, Sakamoto H, Yasukawa H, Masuhara M, Wakioka T, Sasaki A, Yuge K, Komiya S, Inoue A, Yoshimura A.
Journal:
Oncogene.
1998
Year:
Vol.&Pages:
17(17)
2271-8.
DOI :
10.1038/sj.onc.1202143.
9811457
PMID:
Pubmed URL:
*Featured on the web of AAAS/ Eureka Alert, LONG ROOM, eCancer News, Specialty Pharmacy Times, Apple News, Research MOZ, Drug Target Review, Science Magazine, News Beezer, Agenparl, ETHIOPIA, Medical Xpress, Science Daily, Life Extension Advocacy Foundation, Asian Telegraph, Oncology Tribune, Qlifepro, Research-Japan
Journal:
Year:
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DOI :
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